Endocrine Abstracts

Introduction: Amino-Bisphosphonates (N-BPs) are potent inhibitors of the bone resorption, they inhibit enzymes of the intracellular mevalonate pathway required for prenylation of different important signaling proteins. In order to study the genetic basis of the variability in therapy response we have analysed the polymorphism of farnesyl pyrophosphate-synthase (FDPS) gene in 234 postmenopausal Danish women treated with N-BPs for 1 and 2 years.Methods: Th...

Metastases in the thyroid gland are very rare and their true incidence has not been clearly established. There are few reports of metastases to this gland and most of them are not detected in clinical practice.Although detection of metastases to the thyroid gland usually indicates poor prognosis aggressive surgical and medical treatment in isolated thyroid metastases may be effective as described for renal carcinoma.Malignant melan...